What’s interesting about mitochondria is that they were once bacteria that invaded cells. Through evolution and time, mitochondria became a permanent residence in our cells, working as the powerhouse for most of the cells in our body. While mitochondrial DNA has an “O” or ring shape to allow easy DNA transcription, it is susceptible to damage.
Certain diseases, opiates, chronic stress, and certain prescribed medication can affect the way the body metabolizes NAD+, interfering with the energy production of cells.
Treatments for Mitochondrial Dysfunction:
One of the most effective ways to boost mitochondrial function energy levels is to get adequate rest. While you sleep during your circadian cycle at night, mitochondria are busy being repaired and replenished. Not getting enough sleep can hinder the mitochondria from completing the repair work necessary to fully restore your energy. NAMPT is a key enzyme in your body that is regulated by sleep. The less you sleep, the less active the enzyme becomes and the harder your body has to work to try to maintain healthy mitochondria.
Part of living a healthy life is to maintain an active lifestyle. Making sure you commit to a routine exercise regimen will also improve mitochondria function up to an astonishing 50%. Other improvements from exercise include increased energy production and membrane structure through cardiolipin.
- NAD+ Therapy
Nicotinamide adenine dinucleotide (NAD+) is an important non-protein compound necessary for the energy production in the mitochondria. NAD+ also helps activate sirtuins and PARPS (protective enzymes), both responsible for repairing DNA as well as protecting the cell. The mitochondria are programmed to die after cellular NAD+ levels cross over a certain threshold.